Search results for "Hepatosplenic T-cell lymphoma"

showing 3 items of 3 documents

Challenges and new prospects in hepatosplenic γδ T-cell lymphoma.

2014

Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of lymphoid neoplasms characterized by aggressive clinical behavior and dismal prognosis. Hepatosplenic γδ T-cell lymphoma (γδ-HSTL) is a particular form of PTCL that arises from a small subset of γ/δ T-cell receptor-expressing lymphocytes. γδ-HSTL has a rapidly progressive course and poor outcome due also to its refractoriness to conventional chemotherapy regimens. The very low incidence of γδ-HSTL, along with its propensity to mimic different pathological entities, makes this lymphoma a true diagnostic challenge. In this review, we highlight the biological and clinical features of γδ-HSTL that contribute to making this lymphoma…

Cancer ResearchHepatosplenic T-cell lymphomaSpleenDiseaseBiologyT cell lymphomaAntineoplastic Combined Chemotherapy ProtocolsmedicineHumansT-cell lymphomaPathologicalgamma delta T cell lymphomahepatosplenic T cell lymphomaSplenic NeoplasmsLiver NeoplasmsLymphoma T-Cell PeripheralReceptors Antigen T-Cell gamma-deltaHematologymedicine.diseaseCombined Modality Therapyperipheral T cell lymphomasLymphomaT cell lymphoma; gamma delta T cell lymphomas; hepatosplenic T cell lymphoma; peripheral T cell lymphomasTreatment Outcomemedicine.anatomical_structureOncologyImmunologyConventional chemotherapyBone marrowStem Cell Transplantation
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Gamma-delta T-cell lymphomas.

2009

Peripheral T-cell lymphomas (TCLs) are uncommon neoplasms, accounting for about 12% of all lymphoid tumors worldwide. TCLs in which gammadelta T-cell receptors are expressed (gammadelta TCLs) are extremely aggressive and rare (<1% of lymphoid neoplasms). gammadelta TCLs originate from gammadelta T cells, a small subset of peripheral T cells with direct antigen recognition capability acting at the interface between innate and adaptive immunity. Two distinct gammadelta TCL entities are recognized: hepatosplenic T-cell lymphoma (HSTL) and primary cutaneous gammadelta T-cell lymphoma (PCGD-TCL). HSTL is a well-characterized extranodal lymphoma that has a disguised onset, secondary to intrasinus…

Hepatosplenic T-cell lymphomaT cellGene Rearrangement delta-Chain T-Cell Antigen Receptorchemical and pharmacologic phenomenaprimary cutaneous gamma delta T-cell lymphomaImmune systemmedicineHumansGamma delta T cellLymphoma T-Cell CutaneouClinical Trials as Topicbusiness.industryGene Rearrangement gamma-Chain T-Cell Antigen Receptorgamma delta T-cell receptorMedicine (all)Peripheral T-cell lymphomaLymphoma T-Cell PeripheralReceptors Antigen T-Cell gamma-deltaGene rearrangementmedicine.diseaseAcquired immune systemLymphomaLymphoma T-Cell Cutaneousstomatognathic diseasesmedicine.anatomical_structurehepatosplenic T-cell lymphomaOncologyImmunologyBone marrowbusinessHuman
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Hepatosplenic T-cell lymphoma

2001

Pathologymedicine.medical_specialtyHepatosplenic T-cell lymphomabusiness.industrymedicineHematologymedicine.diseasebusinessBritish Journal of Haematology
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